Inhibitory effect of imidazole on gastric acid secretion
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Effect of Nimbidin on Gastric Acid Secretion
Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti - secretory activity in pylorus ligated rats and cats. In lumen - perfused rats it suppressed the basal as well as histamine and carbachol stimulated gastric acid output at 40 mg/kg (i.v). However it had no effect on ASA - induced back - dif...
متن کاملEffect of Esophageal Distention on Basal and Stimulated Gastric Acid Secretion in Rats
It is well established that the esophageal distention (ED) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ED on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of ED on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240 g) were deprived of food but not the water 24 h b...
متن کاملInhibitory effect of pancreatic secretin on gastric secretion.
GREENLEE, HERBERT B., ENRIQUE H. LONGHI, JOSE DELGADILLO GUERRERO, THOMAS S. NELSEN, ABDUL LATIF EL-BEDRI AND LESTER R. DRAGSTEDT. hhibitwy effect of pmwreatic secretiN on gust& secretion. Am. J. Physiol. 190(3) : 396-402. 1957.---In dogs prepared with both a vagus denervated Heidenhain pouch and a total pancreatic fistula, the intravenous injection of pancreatic secretin (Lilly) produced a pro...
متن کاملInhibitory effect of neurotensin on gastric acid secretion in rats. Development of a bioassay model.
Neurotensin has been shown to inhibit gastric acid secretion when administered in pharmacological doses, but no information has been available concerning its possible dose-related effect during intravenous infusion. In this study, a dose-related and reversible inhibitory effect of neurotensin was demonstrated in pentobarbital-anesthetized female Sprague-Dawley rats. The rats underwent continuou...
متن کاملThe effect of bromocriptine on basal and histamine-stimulated gastric acid secretion in anesthetized rats
Introduction: The protective and antisecretory effects of dopamine agonists on the stomach have been already reported, but the effect of bromocriptine (D2 dopamine agonist) on histamine stimulated gastric acid secretion (GAS) needs to be investigated. Methods: For gastric sampling, animals were anesthetized and a polyethylen tube was introduced into the stomach through esophagus. A cannula ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1975
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)65636-2